Sero-prevalence and risk factors for cytomegalovirus infection among pregnant women in a teaching hospital in Ogun state, Nigeria

Authors

  • C. J. Elikwu
  • I. Otaigbe
  • T. Oluwole
  • O. Shonekan
  • V. Nwadike
  • B. Tayo
  • C. Okangba
  • A. Omeonu
  • B. Faluyi
  • S. Umebuani
  • M. Aluko
  • O. Idowu
  • M. J. Okhagbuzo
  • B. Alabi

Keywords:

Cytomegalovirus, pregnant women, sero-prevalence, risk factors

Abstract

Background: Infection with cytomegalo virus is usually asymptomatic however in pregnant women the risk of congenital infection and foetal abnormalities makes antenatal screening for CMV infection necessary. The aim of this study was to determine the sero-prevalence and risk factors for CMV infection among pregnant women in Babcock University Teaching Hospital (BUTH), Ilishan Remo, Ogun State, Nigeria.

Methods: The study was a cross-sectional descriptive study conducted between January and May, 2017 on patients attending the antenatal clinic of Babcock University Teaching Hospital. Enzyme Linked Immunosorbent Assay (ELISA) Kits were used to determine IgM and IgG anti CMV antibody titresin venous blood samples obtained from study participants.

Results: A total of 80 patients were recruited into the study. The mean age was 30 years.All (100%) respondents were sero-positive for anti CMV IgG antibodies while 28.75% of respondents were seropositive for anti CMV IgM antibodies.

Conclusion: There was a highsero-prevalence rate of CMV infection in the study. Screening of pregnant women for CMV infection is necessary due to the risk of congenital infection and fetal defects.

References

Murray PR, Baron EJ. Manual of Clinical Microbiology. Washington, DC. ASM Press. 2007.

Goodrum F, Caviness K, Zagallo P. Human cytomegalovirus persistence. Cell Microbiol. 2012; 14(5):644-655. doi: 10.1111/j.14625822.2012.01774.x.

Lancini D, Faddy HM, Flower R, Hogan C. Cytomegalovirus disease in immunocompetent adults. Med J Aust. 2014; 201(10):578-80. doi: 10.5694/mja14.00183.

Ronchi A, Zeray F, Lee LE, Owen KE, Shoup AG, Garcia F et al. Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection. J Perinatol. 2020; 40: 89–96. doi: 10.1038/s41372-019-0501-z

Emery VC. Investigation of CMV disease in immunocompromised patients. Journal of Clinical Pathology 2001; 54:84-88. doi: 10.1136/jcp.54.2.84.

Bateman CM, Kesson A, Powys M, Wong M,

Blyth E. Cytomegalovirus Infections in Children with Primary and Secondary Immune

Deficiencies. Viruses. 2021; 13 (10): 2001.

doi:10.3390/v13102001

Schildermans J, De Vlieger G. Cytomegalovirus: A Troll in the ICU? Overview of the Literature and Perspectives for the Future. Front. Med.

; 7:188. doi: 10.3389/fmed.2020.00188

Carlson A, Norwitz ER, Stiller RJ.

Cytomegalovirus infection in pregnancy: should all women be screened? Rev Obstet Gynecol. 2010; 3(4):172-179.

Isikay S, Yilmaz K. Congenital cytomegalovirus infection and finger anomaly. BMJ Case Rep. 2013; 2013:bcr2013009486. doi: 10.1136/bcr2013-009486.

Hadar E, Dorfman E, Bardin R, Gabbay-Benziv R, Amir J, PardoJ.Symptomatic congenital cytomegalovirus disease following non-primary maternal infection: a retrospective cohort study.

BMC Infect Dis. 2017; 17: 31. doi:

1186/s12879-016-2161-3

Araoye M.O. Research Methodology with statistics for health and social sciences. Ilorin. Netadex Publishers. 2003. p.115-21.

Yeroh M, Aminu M, Musa BO. Seroprevalence of cytomegalovirus infection amongst pregnant women in Kaduna State, Nigeria. Afr J ClinExperMicrobiol. 2015; 16(1): 37-44. doi: 10.4314/ajcem.v16i1.7

Umeh EU, Onoja TO, Aguoru CU, Umeh JC. Seroprevalence of Cytomegalovirus Antibodies in Pregnant Women, Benue State, Nigeria. J

Infect Dis Ther. 2015; 3:242doi:10.4172/2332-

1000242

Kumar M, Nizam MB, Mugunthan M.

Seroprevalence of cytomegalovirus infection in antenatal women in a Tertiary Care Center in Western India. J Mar Med Soc 2017;19:51-4doi: 10.4103/jmms.jmms_26_17

Alvarado-Esquivel C, Terrones-Saldivar MDC, Hernandez-Tinoco J, et al. Seroepidemiology of Cytomegalovirus Infection in Pregnant Women in the Central Mexican City of Aguascalientes. J Clin Med Res. 2018;10(4):337-344. doi:

14740/jocmr3358w.

Waseem H, Ali J, Jamil SUU, Ali A, Jameel S. Seroprevalence of Cytomegalovirus among pregnant women in Islamabad, Pakistan. Journal of entomology and zoology studies. 2015; 5: 1788-1791.

el-Nawawy A, Soliman AT, el Azzouni O, Amer el-S, Karim MA, Demian S, el Sayed M: Maternal and neonatal prevalence of toxoplasma and cytomegalovirus (CMV) antibodies and hepatitis-B antigens in an Egyptian rural area. J

T r o p P e d i a t r 1 9 9 6 , 4 2 ( 3 ) : 1 5 4 - 7 . 1 0 . 1 0 9 3 / t r o p e j / 4 2 . 3 . 1 5 4 d o i :

1093/tropej/42.3.154.

Neirukh T, Qaisi A, Saleh N, Rmaileh AA, Zahriyeh EA, QureiL,et al. Seroprevalence of Cytomegalovirus among pregnant women and hospitalized children in Palestine. BMC Infect Dis. 2013; 13:528 doi: 10.1186/1471-2334-13528.

Mustakangas P, Sarna S, Ämmälä P, Muttilainen M, Koskela P et al. Human cytomegalovirus seroprevalence in three socioeconomically different urban areas during the first trimester: a population-based cohort study, International

Journal of Epidemiology.2000; 29 (3)

:3587–591. doi: 10.1093/ije/29.3.587

Porobic-Jahic H, Skokic F, Ahmetagic S, Piljic D, Jahic R, Petrovic J. Cytomegalovirus Infection in Pregnancy - Our Experiences. Med Arch. 2019;

3 ( 3 ) : 1 4 9 - 1 5 3 . d o i :

5455/medarh.2019.73.149-153 21. Odland ML, Strand KM, Nordbø SA, et al. Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sør-Trøndelag County: a crosssectional study. BMJ Open 2013;3: e003066. doi: 10.1136/bmjopen-2013-003066

Knowles SJ, Grundy K, Cahill I, et al. Low cytomegalovirus sero-prevalence in Irish pregnant women. Ir Med J. 2005; 98: 210–12.

Gratacap-Cavallier B, Bosson JL, Morand P, et al Cytomegalovirus seroprevalence in French pregnant women: parity and place of birth as major predictive factors. Eur J Epidemiol 1998; 14:147–52. doi: 10.1023/a:1007450729633.

Balegamire SJ, Renaud C, Mâsse B, Zinszer K, Gantt S, et al. Frequency, timing and risk factors for primary maternal cytomegalovirus infection during pregnancy in Quebec. PLOS ONE. 2021; 16(6): e0252309.

doi:10.1371/journal.pone.0252309

Wujcicka W, Gaj Z, Wilczyñski J, Sobala W, Spiewak E, Nowakowska D. Impact of socioeconomic risk factors on the seroprevalence of cytomegalovirus infections in a cohort of pregnant Polish women between 2010 and 2011.

E u r J C l i n M i c r o b i o l I n f e c t D i s .

;33(11):1951-1958. doi:10.1007/s10096014-2170-3

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Published

2023-10-11

How to Cite

Elikwu, C. J., Otaigbe, I., Oluwole, T., Shonekan, O., Nwadike, V., Tayo, B., Okangba, C., Omeonu, A., Faluyi, B., Umebuani, S., Aluko, M., Idowu, O., Okhagbuzo, M. J., & Alabi, B. (2023). Sero-prevalence and risk factors for cytomegalovirus infection among pregnant women in a teaching hospital in Ogun state, Nigeria. Research Journal of Health Sciences, 10(4), 365–371. Retrieved from https://rjhs.org/index.php/home/article/view/335

Issue

Vol. 10 No. 4 (2022): Research Journal of Health Sciences

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Original Article

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