The impact of radiofrequency electromagnetic radiation from mobile phone on oestrous cycle and reproductive hormones in female wistar rats (Rattus norvegicus)

Authors

  • A. O. Olarinoye
  • A. O. Oyewopo
  • J. K. Olarinoye
  • B. A. Olagbaye

Keywords:

Radiofrequency electromagnetic radiation, Oestrous cycle, Reproductive hormones

Abstract

Aim of Study: The study was aimed at evaluating the impact of radiofrequency electromagnetic radiation (RF-EMR) from mobile phones on the oestrous cycle and reproductive hormones in female Wistar rats.

Methods: Twenty-one Mature female Wistar rats weighing 180 to 250gramswere acclimatized for 2 weeks and divided into control (A), 4hrs (B) and 6hrs (C) groups and were exposed to RE-EMF for a period of 28 days. Oestrous cycle was monitored daily and hormonal level was determined using standardized enzymatic colorimetric methods. One-way analysis of variance was used to compare the mean values of variables among the groups accepting statistical significance at p≤ 0.05.

Results: Oestrous cycle was deranged in experimental group compared to the control. Mean serum level of Follicle stimulating hormone (FSH) in control group remained low compared to the exposed groups. Luteinizing hormone (LH) levels in group A were almost double that of the group B and C, while the serum level of Oestrogen was lowest in group A. Progesterone level in the control group was higher than the experimental group

     


Conclusion: RF EMR showed an adverse effect on the weight and oestrous cycle but the effect on the reproductive hormones is not significant although the effect appeared to be related to the duration of exposure.

References

Roelandts R. Cellular phones and the skin. Dermatology. 2003 Jul 10;207(1):3.

Kaszuba-Zwoiñska J, Gremba J, Ga³dziñska-Calik B, Wójcik-Piotrowicz K, Thor PJ. Electromagnetic field induced biological effects in humans. PrzegladLekarski. 2015 Jan 1;72(11):636-41.

Sieroñ-Sto³tny K, Teister £, Cieœlar G, Sieroñ D, Œliwinski Z, Kucharzewski M, Sieroñ A. The influence of electromagnetic radiation generated by a mobile phone on the skeletal system of rats. BioMed research international. 2015 Feb 1;2015.

Merhi ZO. Challenging cell phone impact on reproduction: a review. Journal of assisted reproduction and genetics. 2012 Apr 1;29(4):2937.

Oyewopo AO, Olaniyi SK, Oyewopo CI, Jimoh AT. Radiofrequency electromagnetic radiation from cell phone causes defective testicular function in male Wistar rats. Andrologia. 2017 Dec;49(10):e12772.

Oyewopo AO, Olaniyi SK, Oyewopo CI, Jimoh

AT. Cell phone alters oxidative status and impairs testicular function of male wistar rats. J. Reprod. Endocrinol. Infertil. 2017;2(1):22.

Altun G, Deniz ÖG, Yurt KK, Davis D, Kaplan S. Effects of mobile phone exposure on metabolomics in the male and female reproductive systems. Environmental research. 2018 Nov 1;167:700-7

Yüksel M, Nazýroðlu M, Özkaya MO. Long-term exposure to electromagnetic radiation from mobile phones and Wi-Fi devices decreases plasma prolactin, progesterone, and estrogen levels but increases uterine oxidative stress in pregnant rats and their offspring. Endocrine. 2016 May 1;52(2):352-62.

Gul A, Çelebi H, Uðraþ S. The effects of microwave emitted by cellular phones on ovarian follicles in rats. Archives of Gynecology and Obstetrics. 2009 Nov 1;280(5):729-33.

Odacý E, Özyýlmaz C. Exposure to a 900 MHz electromagnetic field for 1 hour a day over 30 days does change the histopathology and biochemistry of the rat testis. International journal of radiation biology. 2015 Jul 3;91(7):547-54.

Okechukwu CE. Effects of mobile phone radiation and exercise on testicular function in male Wistar rats. Nigerian Journal of Experimental and Clinical Biosciences. 2018 Jul 1;6(2):51.

Sepehrimanesh M, Davis DL. Proteomic impacts of electromagnetic fields on the male reproductive system. Comparative Clinical Pathology. 2017 Mar 1;26(2):309-13.

Sepehrimanesh M, Saeb M, Nazifi S, Kazemipour N, Jelodar G, Saeb S. Impact of 900 MHz electromagnetic field exposure on main male reproductive hormone levels: a Rattusnorvegicus model. International journal of biometeorology. 2014 Sep 1;58(7):1657-63.

deSeze R, Fabbro-Peray P, Miro L. GSM radiocellular telephones do not disturb the secretion of antepituitary hormones in humans. Bioelectromagnetics: Journal of the

Bioelectromagnetics Society, The Society for Physical Regulation in Biology and Medicine, The European Bioelectromagnetics Association. 1998;19(5):271-8.

Batellier F, Couty I, Picard D, Brillard JP. Effects of exposing chicken eggs to a cell phone in “call” position over the entire incubation period. Theriogenology. 2008 Apr 1;69(6):737-45.

Diem E, Schwarz C, Adlkofer F, Jahn O, Rüdiger H. Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in

transformed GFSH-R17 rat granulosa cells in vitro. Mutation Research/Genetic Toxicology and

Environmental Mutagenesis. 2005 Jun

;583(2):178-83.

Roshangar L, Hamdi BA, Khaki AA, Rad JS, Soleimani-Rad S. Effect of low-frequency electromagnetic field exposure on oocyte differentiation and follicular development. Advanced biomedical research. 2014;3.

Nazýroðlu M, Yüksel M, Köse SA, Özkaya MO. Recent reports of Wi-Fi and mobile phone-induced radiation on oxidative stress and reproductive signaling pathways in females and males. The

Journal of membrane biology. 2013 Dec

;246(12):869-75.

Nisbet HO, Akar A, Nisbet C, Gulbahar MY, Ozak A, Yardimci C, Comlekci S. Effects of electromagnetic field (1.8/0.9 GHz) exposure on growth plate in growing rats. Research in Veterinary Science. 2016 Feb 1;104:24-9.

Fahmy HM, Mohammed FF, Abdelrahman RT, Abu Elfetoh MM, Mohammed YA. Effect of radiofrequency waves emitted from conventional WIFI devices on some oxidative stress parameters in rat kidney. J Drug MetabToxicol. 2015;6(195):2.

Aziz IA, EL-KhozondarHJ, Shabat M, ElwasifeK, Mohamed-Osman A. Effect of electromagnetic field on body weight and blood indices in albino rats and the therapeutic action of vitamin C or E. Education. 1995 May; 1999.

Smialowicz RJ, Weil CM, Kinn JB, Elder JA. Exposure of rats to 425-MHz (CW) radiofrequency radiation: Effects on lymphocytes. Journal of Microwave Power. 1982 Jan 1;17(3):211-21.

Tsuji Y, Nakagawa M, Suzuki Y. Five-tesla static magnetic fields suppress food and water consumption and weight gain in mice. Industrial health. 1996;34(4):347-57.

Asghari A, Khaki AA, Rajabzadeh A, Khaki A. A review on Electromagnetic fields (EMFs) and the reproductive system. Electronic physician. 2016 Jul;8(7):2655.

Gye MC, Park CJ. Effect of electromagnetic field exposure on the reproductive system. Clinical and experimental reproductive medicine. 2012 Mar;39(1):1.

Mikolajczyk H. 1978. Biological effects of electromagnetic fields below 300 MHz

(pregnancy, litter size and gonadotropic activity of the anterior pituitary gland). Med Pr 29: 111–120.

Black DR, Heynick LN. Radiofrequency (RF) effects on blood cells, cardiac, endocrine, and immunological functions. Bioelectromagnetics. 2003;24(S6):S187-95.

Yu C, Peng RY. Biological effects and mechanisms of shortwave radiation: a review. Military Medical Research. 2017 Dec;4(1):1-6.

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Published

2023-10-10

How to Cite

Olarinoye, A. O., Oyewopo, A. O., Olarinoye, J. K., & Olagbaye, B. A. (2023). The impact of radiofrequency electromagnetic radiation from mobile phone on oestrous cycle and reproductive hormones in female wistar rats (Rattus norvegicus) . Research Journal of Health Sciences, 9(3), 282–288. Retrieved from https://rjhs.org/index.php/home/article/view/291