Advantage of the regenerative potentials of the periosteum especially in children, Oghara experience: A case series
Keywords:
Periosteum, mesenchymal stem cells, bone defects, distraction histiogenesisAbstract
The periosteum is a composite tissue comprising an outer protective fibrovascular layer and an inner cambium regenerative pluripotent layer. The regenerative function of periosteum has been put to clinical use by dental surgeons to manage alveolar ridge reduction and by tissue engineers to produce autologous micrograft and collagen used to manage complex wounds and scars. The essence of this study is to add to the body of knowledge on clinical use of periosteum to treat bone defects from the orthopaedic perspective. We highlight a case series to demonstrate the use of periosteum in managing bone defects caused by benign bone tumour, chronic osteomyelitis, tibial hemimelia and traumatic bone loss of the distal tibia in Delta State University Teaching Hospital, Oghara. Treatment of bone defects by this means is cost effective and the outcome is very satisfactory.
References
d'Aquino R, Trovato L, Graziano A, Ceccarelli G, et al. Periosteum derived micro-grafts for tissue regeneration of Human Maxillary bone. Journal of Translational Science 2016; 2(2):125-29.
Dwek JR. The Periosteum: What is it, where is it, and what mimics it in its absence? Skeletal Radiology 2010;39(4):319-23
Concise Review: The Periosteum; Tapping into a Reservoir of Clinically Useful Progenitor Cells. Stem Cell Transl. Med.2012; 1(6):480-91. [Cross Ref]
Shapiro F. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater. 2008; 15:53–76.]
Knothe Tate ML, Ritzman TF, Schneider E, et al. Testing of a new one-stage bone-transport surgical procedure exploiting the periosteum for the repair of long-bone defects. J Bone Joint Surg Am. 2007; 89:307–316.
Modric J. ''Periosteum''. eHealthStar. Retrieved 15 June 2017.
Arnsdorf EJ, Jones LM, Carter DR, Jacobs CR. The Periosteum as a Cellular source for functional tissue engineering. Tissue Eng. Part A. 2009; 15(9): 2637-42.
Ferretti C, Mattioli-Belmonte M (2014) Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge. World J Stem Cells 6: 266-277.
Hosny GA. Treatment of Tibial hemimelia without amputation. J. Paediatric Orthop. B.2005;14(4):250.
Enemudo RE. Management of Tibial hemimelia: A Case Report. Nigerian Journal of Orthopaedics and Trauma.2013;12(2):128-33.
Enemudo RET, Odatuwa-Omagbemi DO, Otene CI, Emina BK, Onyeokweanwa CE. Distraction Osteogenesis in the Management of Bone Gaps. Nigeria Journal of Orthopaedics and Trauma. 2013;12(2):107-112.
Gurdayal SK, Pradeep G, Pradeep KS. Reconstruction of post traumatic long bone defects with vascularized fibula. A series of 28 cases. India J. of Plastic Surgery. 2013; 46(3):54346.
Yongu and Isa. Femoral lengthening using Ilizarov Technique in Nigeria: National
Orthopaedic Hospital Dala Experience. Nig
Journal of Orthop and Trauma. 2010;9 (2):58-60
Ahmed MT, Paley D, Kocaoglu M, Eralp L, Herzenberg JE, Ergin ON. Periosteal grafting for
Congenital Pseudoarthrosis of Tibia: A
Preliminary Report. Clinical Orthop. Related Res. 2008; 466(12): 2981-94
Lee DY, Cho TJ, Lee HR, Lee k et al. Disturbed Osteoblastic differentiation of Fibrous
Hamartoma cells from Congenital
Pseudoarthrosis of the tibia associated with Neurofibromatosis type I. Clinical Orthop. Surg. 2011;3(3):230-7.
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