Adherence to prescribed drug therapy among adult patients of General Out-Patient Department of a Tertiary Hospital in Nigeria
Keywords:
Drug, adherence, Teaching, Hospital, NigeriaAbstract
Objective: The widespread problems of adherence to medication denied substantial number of patients the maximum benefits of medical treatment, resulting in poor health outcomes, lower quality of life and increased health care costs. The objective of this study was to determine the extent of drug adherence among patients seen in a tertiary hospital in Nigeria.
Methods: The study was a descriptive cross-sectional survey carried out among 381 patients attending the General Out-Patient Department (GOPD) of a Teaching Hospital in Nigeria. Interviewer administered questionnaire was used as the research tool and case notes of the patients were used to obtain information on drug adherence.
Results: About half of the patients 194 (50.9%) adhered fully with doctor's prescription on the use of drugs for diseases they presented to the hospital. More than three quarters (78.0%) of patients aged 56 years and above adhered fully with prescription compared with 11.1% in the age group 15-25 years. The older patients had better adherence to medication than the younger patients with a statistically significant difference (p = 0.001). Many of the patients with no formal education (69.0%) adhered fully with prescription compared with 28.6% with post secondary education p = 0.001.
Conclusion: Health education intervention and active role of health care providers in patients'-provider communication towards addressing the determinants of non-adherence will play a major role in improving adherence to medication
References
Sabaté E. Project WA to LTT, network GAI, diseases WHOD of M of N. Adherence to longterm therapies: evidence for action. http://www. who. int/ iris/ handle/ 10665/42682 (cited 25 Sep 2017).
Ferdinand KC, Senatore FF, Clayton-Jeter H, et al. Improving Medication Adherence in Cardiometabolic Disease. J Am Coll Cardiol
;69:437–51.8
Thinking outside the Pillbox: A System-wide
Approach to Improving Patient Adherence for
Chronic Disease." NEHI. 2009
Eaddy MT, Cook CL, O'Day K, Burch SP,
Cantrell CR (2012). "How Patient Cost Sharing Trends Affect Adherence and Outcomes: A Literature Review".Pharmacy and Therapeutics. 37 (1): 45–55.
Kesselheim AS, Avorn J, Sarpatwari A (2016). "The High Cost of Prescription Drugs in the
United States Origins and Prospects for Reform". JAMA. 316 (8): 858–871. d o i : 1 0 . 1 0 0 1 / j a m a . 2 0 1 6 . 1 1 2 3 7
(https://doi.org/10.1001%2Fjama.2016.11237).
Kaiser Family Foundation: Poll Finds Nearly Three Quarters of Americans Say Prescription Drug Costs Are Unreasonable, and Most Blame Drug Makers Rather Than Insurers for the Problem
Kennedy J, Morgan S. "Cost-related prescription non adherence in the United States and Canada: A system-level comparison using the 2007 international health policy survey in seven countries"Clinical Therapeutics. 31 (1): 213–219. doi:10.1016/j.clinthera.2009.01.006
(https://doi.org/10.1016%2Fj.clinthera.2009.01
.006.)
"Enhancing Patient Adherence: Proceedings of the Pinnacle Roundtable Discussion ("http://www.pharmacist.com/AM/Template.cf m?Section=Home2&TEMPLATE=/CM/Conte ntDisplay.cfm&CONTENTID=11174). APA
Highlights Newsletter. October 2004.
Ngoh LN (2009). "Health literacy: a barrier to pharmacist-patient communication and medication adherence J" .Am Pharm Assoc (2003). 49 (5): e132–46; quiz e147–9. d o i : 1 0 . 1 3 3 1 / J A P h A . 2 0 0 9 . 0 7 0 7 5 ( h t t p s : / / d o i . o r g / 1 0 . 1 3 3 1 % 2 F J A PhA.2009.07075). PMID 19748861
(https://www.ncbi.nlm.nih.gov/pubmed/197488 61).
Elliott RA, Marriott JL (2009). "Standardised assessment of patients' capacity to manage medications: a systematic review of published
i n s t r u m e n t s "
(https://www.ncbi.nlm.nih.gov/pmc/articles/P
MC2719637). BMC Geriatr. 9: 27. d o i : 1 0 . 1 1 8 6 / 1 4 7 1 - 2 3 1 8 - 9 - 2 7
(https://doi.org/10.1186%2F1471-2318-9-27.)
P M C 2 7 1 9 6 3 7
(https://www.ncbi.nlm.nih.gov/pmc/articles/P
M C 2 7 1 9 6 3 7 ) . P M I D 1 9 5 9 4 9 1 3
(https://www.ncbi.nlm.nih.gov/pubmed/195949 13).
Berhe DF, Taxis K, Haaijer-Ruskamp FM, Mulugeta A, Mengistu YT , Burgerhof JG, Mol PG (2017). "Impact of adverse drug events and treatment satisfaction on patient adherence with antihypertensive medication – a study in ambulatory patients". Br J Clin Pharmacol. d o i : 1 0 . 1 1 1 1 / b c p . 1 3 3 1 2
(https://doi.org/10.1111%2Fbcp.13312)PMID2
4 2 9 5 3 3
(https://www.ncbi.nlm.nih.gov/pubmed/284295 33).
Nieuwlaat, Robby; Wilczynski, Nancy; Navarro, Tamara; Hobson, Nicholas; Jeffery, Rebecca; Keepanasseril, Arun; Agoritsas, Thomas; Mistry, Niraj; Iorio, Alfonso (2014-11-20). "Interventions for enhancing medication adherence".The Cochrane Database of Systematic Reviews (11): CD000011. doi:10.1002/14651858.CD000011.pub4(https:// doi.org/10.1002%2F14651858.CD000011.pub4. ) I S S N 1 4 6 9 - 4 9 3 X
(https://www.worldcat.org/issn/1469-493X).
P M I D 2 5 4 1 2 4 0 2
(https://www.ncbi.nlm.nih.gov/pubmed/254124 02).
Sandra van Dulmen, Enmy Sluijs, Liset van
Dijk, Deniscde Ridder, Rob Heardink and Jozican Bersing. Patient adherence to medical treatment: a review of reviews. BMC Health Science Research 2007, 7; 55: 1-13.
Hashmi SK, Afridi MB, Abbas K, Sajwani RA, Saleheen D, Frossard PM, Ishaq M, et al. Factors associated with adherence to anti-hypertensive treatment in Pakistan. Journal plosome 2007 (3) accessed online on 20/12/2016 @ www.plosome.org
Hassan NB, Hasanah CI, Foong K, Naing I, Awang R. Identification of psychological factors of non-compliance in hypertensive patients. J Hum Hypertens 2006, 20; 23-29
Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM. The significance of compliance and persistence in the treatment of diabetes, hypertension and dsylipidaemia. Int J Clin Pract 2008, 62 (1): 76-87.
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