A profile of blood pressure changes in patients on anti-retroviral treatment in a tertiary health centre in Nigeria

Authors

  • S. Ajayi
  • A. Adebiyi
  • M. Mamven
  • P. Dakum

Keywords:

HIV-infection, anti-retroviral, high blood pressure changes

Abstract

Introduction: HIV-infected individuals live longer due to life-saving antiretroviral
treatment (ART), their risk for other comorbidities like hypertension increases.
Therefore, the risk factors of developing hypertension in these patients may include
co-morbidities like obesity and effects of combination anti-retroviral therapy
(cART).This study of both cART-naïve and cART-experienced patients aimed to
determine the profile of blood pressure changes.
Methods: This was a retrospective analysis of data obtained from HIV care and
treatment records at a treatment centre for HIV. To study blood pressure changes over
the course of treatment and follow-up and the use of cART, we categorized the study
population into three: those who had not been commenced on cART, those who were
on cARTfor up to 1 year, and those who were on cARTfor more than one year.
Results:There were 6,325 patients with complete data suitable for analysis, of which
there were 4,112 females (65%). The levels of all blood pressure phenotypes
increased over the treatment period for the study participants. The first and last SBP
were higher for patients on cARTfor more than one year than on patients who were on
cART for about one year (110.6(6.07) vs 108.1(15.31) mmHg, p<0.001 and
113.3(15.30) mmHg vs 109.4(15.18) mmHg, p<0.001). The maximum SBPwas also
highest at 130.9(17.25) mmHg for patients who were on cART for more than one
year. Similarly, DBP was higher in those who were on cART for more than 1 year.
The mean arterial pressure was also higher, from 83.1(8.03) to 85.7(7.62) mmHg
(p<0.001).
Conclusion: The blood pressure phenotypes showed a consistent increase in those
who were on cART for more than one year compared to those on cART for 1 year or
less.

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Published

2024-07-21

How to Cite

Ajayi, S., Adebiyi, A., Mamven, M., & Dakum, P. (2024). A profile of blood pressure changes in patients on anti-retroviral treatment in a tertiary health centre in Nigeria. Research Journal of Health Sciences, 12(2), 313–319. Retrieved from https://rjhs.org/index.php/home/article/view/396

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Vol. 12 No. 2 (2024): Research Journal of Health Sciences

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Original Article

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