Morphoanatomy of striated myofibers in streptozotocin-induced diabetic wistar rats: assuaging effect of combined doses of Vernonia amygdalina and Azadirachta indica

Authors

  • O. E. Yama
  • O. V. Adeteye
  • T. O. Kusemiju
  • O. M. Avidime
  • T. Danboyi
  • A. A. Odetola
  • K. A. Mohammed

Keywords:

diabetic, extract, glutathione, peroxidase

Abstract

Objective: This study aimed to evaluate the effects of Azadirachta indica and Vernonia amygdalina extracts on the morphoanatomy of striated myofibrils in diabetic rat models.

Methodology: Thirty Wistar rats randomly assigned into 5 groups of 6 rats/group were used. Group A received distilled water only, B (herbal) received A. indica (500 mg/kg/day) and V. amygdalina (400 mg/kg/day) simultaneously, C were diabetic rats, D were diabetic rats treated with herbal extracts combined and E, diabetic rats treated with metformin. Diabetes was induced with streptozotocin (70 mg/kg). Muscles glutathione peroxidase (GPx) and blood glucose levels were determined. The rats were sacrificed at the end of 60days treatment. The quadriceps femoris muscle harvested for histology.

Results: Diabetic herbal treated rats became euglycemic by the end of 8 weeks. GPx activity was significantly (p<0.05) elevated compared to control. The histology of skeletal muscle fibers of the diabetic rats treated with herbal formulation and metformin showed minimal level of damage.

Conclusions: The findings in this study showed that the herbal formulation could be used in treatment of diabetes and in ameliorating the associated muscular cytoarchitectural alterations.

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Published

2023-10-08

How to Cite

Yama, O. E., Adeteye, O. V., Kusemiju, T. O., Avidime, O. M., Danboyi, T., Odetola, A. A., & Mohammed, K. A. (2023). Morphoanatomy of striated myofibers in streptozotocin-induced diabetic wistar rats: assuaging effect of combined doses of Vernonia amygdalina and Azadirachta indica. Research Journal of Health Sciences, 8(2), 92–101. Retrieved from https://rjhs.org/index.php/home/article/view/241

Issue

Vol. 8 No. 2 (2020): Research Journal of Health Sciences

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Original Article

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